Cephalonikin, formerly known as IMC-2 (Imulsion Mutagenic Compound 2), is a small-molecule chemical mutagen that binds to the minor groove of deoxyribonucleic acid (DNA) polymers in GC-enriched regions. It is a natural product found in imulsion extract that was shown to at least in part mediate the neuropsychological phenotype induced by exposure to high concentrations of imulsion extract.
Cephalonikin was originally identified as a small-molecule residing in imulsion extract with a high affinity for human cell lysates by Davis et. al in 2532 at the Bastion Public Health Service. Shortly afterwards, it was characterized by Murchie et. al in 2532 at the Harridan University Medical School as a DNA mutagen with an affinity for CACNA1C (the L-type Ca+2 channel) that was independently capable of phenocopying the neuropsychological pathological phenotype of imulsion extract in mice.
- ↑ Davis et. al. (2532). Identification of mutagenic small molecules from imulsion extract. Nature (541): 173-177.
- ↑ Murchie et. al (2532). Behavioral defects induced by imulsion extract mediated by a defined neuronal genetic mutagen. Nature (541): 173-177.