Cyclogenol ("EP 163498") is a specific small-molecule inhibitor of CDKN1B (p27Kip1) that is naturally found in imulsion extract and is believed to in part mediate imulsion's mutagenic properties to the adult human. It was originally characterized by Ellis Pharmaceuticals in their studies of imulsion extract and in the Ellis Pharmaceutical internal collection, is referenced as "EP 163498".
It has been previously shown that abrogation of p27Kip1 in mice induces global cellular hyperplasia by increases in organ cellular density and increased mean body and organ size and that even haploinsufficiency of p27Kip1 leads to removal of its tumor suppressor activity.
- ↑ Fero et. al (1996). A Syndrome of Multiorgan Hyperplasia with Features of Gigantism, Tumorigenesis, and Female Sterility in p27Kip1-Deficient Mice. Cell (85): 733-744.
- ↑ Fero et. al (1998). The murine gene p27Kip1 is haplo-insufficient for tumour suppression. Nature (396): 177-180.
Behind the ScenesEdit
- While Cyclogenol is a fictitious inhibitor of CDKN1B, the biological activities of CDKN1B described are indeed real-world, and Fero et. al (1996) and Fero et. al (1998) are real world publications in Cell and Nature, respectively.